Zinc finger RANBP2-type containing 1 (ZRANB1) is a deubiquitinase which is part of the OTU family. It possesses an ovarian tumor (OTU) catalytic domain. This 708 amino acid protein consists of three amino-terminal Npl4-like zinc finger (NZF) domains. The ZRANB1 gene is localized on human chromosome 10q26.13.
Immunogen
Peptide with sequence KWLDRYRQIRPCTS from the C Terminus of the protein sequence according to NP_060050.2.
Biochem/physiol Actions
Zinc finger RANBP2-type containing 1 (ZRANB1) is a positive modulator of Wnt signaling pathways. It hydrolyzes K29- and K33-linked ubiquitin chains.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.
Licchesi JD
Nature Structural and Molecular Biology (2011)
K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Kristariyanto YA
Molecular Cell (2015)
Rare copy number variation in cerebral palsy
Gai McMichael
European Journal of Human Genetics (2014)
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