Integrin α M (ITGAM) is also called as cluster of differentiation 11b (CD11b) or intercellular adhesion molecule-1 (ICAM-1). It is expressed on monocytes/macrophages, natural killer cells, neutrophils and a subset of B-and T-lymphocytes. ITGAM gene is located on human chromosome 16p11.
Immunogen
Peptide with sequence C-RNDGEDSYRTQ from the internal region of the protein sequence according to NP_000623.2 .
Biochem/physiol Actions
Integrin α M (ITGAM) is involved in cell activation, chemotaxis, cytotoxicity and phagocytosis. It modulates the interaction of leukemic cells with microenvironment by binding inactivated complement component 3b (iC3b), intercellular adhesion molecule (ICAM), fibrinogen, beta-glukanes, coagulation factor X etc. ITGAM is considered as a marker for myeloid-derived suppressor cells that participates in restraining antitumor immunity of the host and inducing the enlargement and drug-resistance of hematological malignant cells. D11b integrin contributes to ICAM-1-dependent AIDP patient mononuclear leukocyte adhesion.
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Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus.
Nath SK, et al.
Nature Genetics, 40(2), 152?154-152?154 (2008)
The pathogenic relevance of ?M-integrin in Guillain?Barre syndrome.
Dong C, et al.
Acta Neuropathologica, 132(5), 739-752 (2016)
Prognostic value of CD11b expression level for acute myeloid leukemia patients: a meta-analysis.
Xu S, et al.
PLoS ONE, 10(8), e0135981-e0135981 (2015)
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