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RAB1050

Sigma-Aldrich

Human Galectin-8 ELISA Kit

for cell culture supernatants, plasma, and serum samples

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type plasma
sample type serum sample(s)
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.16 ng/ml

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... LGALS8(3964)

General description

This ELISA antibody pair detects Human Galectin-8 (LGALS8)

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Galectin-8 (Gal-8) is a member of “tandem-repeat” galectin family, possesses two carbohydrate binding domains linked by a short peptide. The short peptide accounts for Gal-8 cell adhesion and downstream signalling. Tumor cells, as well as normal tissues, express Gal-8. The expression level of Gal-8 is higher in multiple myeloma conditions and enhances adhesion to vascular endothelium. Galectin-8 binds to integrin selectively and inhibits cell adhesion and promotes apoptosis. Gal-8 interacts with integrin alpha and regulates neutrophil adhesion to endothelial cells and migration. Gal-8 ligand binds to cluster of differentiation 44 (CD44) and causes an inflammatory response in rheumatoid arthritis. Overexpression of Gal-8 plays a key role in metastasis of prostate cancer and cell survival by causing rearrangement of the cytoskeleton and E-cadherin expression.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Galectin-8 modulates neutrophil function via interaction with integrin alphaM
Nishi N, et al.
Glycobiology, 13(11), 755-763 (2003)
The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation
Sebban LE, et al.
Journal of Immunology, 179(2), 1225-1235 (2007)
Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
Hadari YR, et al.
Journal of Cell Science, 113(13), 2385-2397 (2000)
Galectin-8 enhances adhesion of multiple myeloma cells to vascular endothelium and is an adverse prognostic factor
Friedel M, et al.
Glycobiology, 26(10), 1048-1058 (2016)
Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer
Gentilini LD, et al.
Oncotarget, 8(27), 44654-44668 (2017)

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