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PZ0177

Sigma-Aldrich

OSU6162 hydrochloride

≥98% (HPLC)

Synonym(s):

PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride

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5 MG
€108.00
25 MG
€311.00

€108.00

Estimated to ship onJune 02, 2025

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5 MG
€108.00
25 MG
€311.00

About This Item

Empirical Formula (Hill Notation):
C15H23NO2S·HCl
CAS Number:
156907-84-5
Molecular Weight:
317.87
MDL number:
MFCD09753276
UNSPSC Code:
51111800
PubChem Substance ID:
329823751
NACRES:
NA.77

€108.00

Estimated to ship onJune 02, 2025

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -5 to -7°, c = 1 in methanol

color

white to tan

solubility

H2O: ≥16 mg/mL

storage temp.

−20°C

SMILES string

Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O

InChI

1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1

InChI key

LEMGVHZVBREXAD-PFEQFJNWSA-N

Biochem/physiol Actions

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.
OSU6162 is a dopamine stabilizer

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
091M4731V

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Nelleke Tolboom et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(2), 472-479 (2014-09-25)
(-)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (-)-OSU6162 in the human brain was investigated using positron emission tomography (PET). Twelve male healthy volunteers underwent [(11)C]raclopride PET scanning

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