Myeloid differentiation primary response 88 (MYD88) is a cytosolic soluble adaptor protein. It possesses a toll-interleukin 1 receptor domain and a death domain. The gene encoding this protein is localized on human chromosome 3p22.2.
Immunogen
a peptide corresponding to amino acids 233-248 of human MyD88, which differ from mouse by two amino acids.
Biochem/physiol Actions
Myeloid differentiation primary response 88 (MYD88) activates innate immune response to Mycobacterium tuberculosis. It is an activator of nuclear factor κ B (NF-κB).The protein mediates the signaling pathways of toll-like and interleukin-1 receptors. Mutation in the gene encoding MYD88 is associated with diffuse large B-cell lymphoma.
Linkage
The action of this antibody can be blocked using blocking peptide SBP2125.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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Regional copy number?independent deregulation of transcription in cancer
Nicolas Stransky
Nature Genetics, 38(12) (2006)
Conformational dynamics of cancer-associated MyD88-TIR domain mutant L252P (L265P) allosterically tilts the landscape toward homo-dimerization.
Zhan C
Protein engineering, design & selection : PEDS, 29(9), 347-354 (2016)
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