L2515
Lipoteichoic acid from Staphylococcus aureus
bacterial cell wall polymer
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About This Item
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biological source
Staphylococcus aureus
Quality Level
form
lyophilized powder
functional group
phospholipid
lipid type
polymerizable lipids
shipped in
ambient
storage temp.
2-8°C
General description
Lipoteichoic acid (LTA) is a linear polymer of phosphodiester-linked glycerol phosphate covalently bound to a lipid. The C2 position on the glycerol-phosphate is usually glycosylated or D-alanylated. LTA is amphipathic due to the presence of the negatively charged backbone of glycerol phosphate and the hydrophobic lipid. The lipid portion is bound hydrophobically to the cell membrane, whereas the polyglycerol phosphate portion extends into the cell wall.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.
Application
Lipoteichoic acid from Staphylococcus aureus has been used:
- to investigate the binding properties of SpHyastatin to lipopolysaccharides and lipoteichoic acid using enzyme-linked immunosorbent assay (ELISA)
- to measure the interleukin (IL-6) produced in splenocytes using a sandwich ELISA
- as a toll-like receptor 2/6 (TLR2/6) agonist to explore its potential to induce tumoricidal M1 macrophage phenotype
Biochem/physiol Actions
Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a complex component of the cell walls of Gram-positive bacteria that are implicated in a wide range of cellular processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of Gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity, and functions versus other bacterial LTAs.
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Simin Rezania et al.
Cancer cell international, 14, 54-54 (2014-06-27)
Many types of tumors are organized in a hierarchy of heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated with different responsiveness to microenvironment stimuli. In the present study, the effects of lipopolysaccharide (LPS) and lipoteichoic acid
S Morath et al.
The Journal of experimental medicine, 193(3), 393-397 (2001-02-07)
Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus aureus, the clinically most frequent Gram-positive pathogen, was inactive after purification. Here, a novel isolation procedure to prepare pure (>99%) biologically active
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Varenka J Barbero-Becerra et al.
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Ingmar J J Claes et al.
Microbial cell factories, 11, 161-161 (2012-12-18)
Probiotic bacteria are increasingly used as immunomodulatory agents. Yet detailed molecular knowledge on the immunomodulatory molecules of these bacteria is lagging behind. Lipoteichoic acid (LTA) is considered a major microbe-associated molecular pattern (MAMP) of Gram-positive bacteria. However, many details and
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