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Key Documents

I4638

Sigma-Aldrich

Interleukin-1β Fragment 163-171 human

≥97% (HPLC), synthetic

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About This Item

Empirical Formula (Hill Notation):
C39H64N12O19
CAS Number:
Molecular Weight:
1004.99
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:

biological source

synthetic

Assay

≥97% (HPLC)

form

powder

mol wt

Mw 1004.99

packaging

pkg of 1 mg

color

white

solubility

water: soluble 1 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

SMILES string

CC(C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t18-,19-,20-,21-,22-,23-,24-,31-/m0/s1

InChI key

NIXBZDOQHRZFDR-OEWCNXHOSA-N

Gene Information

human ... IL1B(3553)

Amino Acid Sequence

Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys

Biochem/physiol Actions

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Daljinder K Kahlon et al.
Bioorganic & medicinal chemistry, 17(8), 3093-3103 (2009-03-31)
We herein describe the synthesis and anti-inflammatory properties of a small library of imidazoline-based NF-kappaB inhibitors. The structure-activity relationship of various substituents on an imidazoline core structure was evaluated for the ability to inhibit NF-kappaB mediated IL-6 production. Optimization of
Yukio Mano et al.
Gynecologic and obstetric investigation, 68(3), 145-153 (2009-07-25)
In the present study, we investigated the participation of inflammatory cytokine-induced mediated matrix metalloproteinase (MMP) expressions and inhibition of interleukin (IL)-6-induced MMP secretion in amniotic epithelial cells by tocilizumab. To investigate the role of MMP expressions, immunohistochemical staining was performed
Tiziana Genovese et al.
Brain research, 1372, 92-102 (2010-12-09)
NADPH oxidase is a major complex that produces reactive oxygen species (ROSs) during the ischemic period and aggravates brain damage and cell death after ischemic injury. Although many approaches have been tested for preventing production of ROSs by NADPH oxidase
Nurdan Bedirli et al.
Anesthesia and analgesia, 106(3), 830-837 (2008-02-23)
We investigated the effects of isoflurane and sevoflurane in a warm liver ischemia-reperfusion (IR) model on cytokines, hepatic tissue blood flow (HTBF), energy content, and liver structure. Seventy-two Wistar rats were randomly assigned into 1 of 3 groups: Control group
Paneth cells and inflammation dance together in Crohn's disease.
Arthur Kaser et al.
Cell research, 18(12), 1160-1162 (2008-12-02)

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