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H168

Sigma-Aldrich

R(+)-7-Hydroxy-DPAT hydrobromide

>98%, solid

Synonym(s):

R(+)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, R(+)-7-Hydroxy(dipropylamino)tetralin hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H25NO · HBr
CAS Number:
82730-72-1
Molecular Weight:
328.29
MDL number:
MFCD00153809
UNSPSC Code:
12352200
PubChem Substance ID:
24278481

Assay

>98%

form

solid

color

white

solubility

H2O: >100 mg/mL
ethanol: >56 mg/mL

SMILES string

Br.CCCN(CCC)C1CCc2ccc(O)cc2C1

InChI

1S/C16H25NO.BrH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H

InChI key

ODNDMTWHRYECKX-UHFFFAOYSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

Selective D3 dopamine receptor agonist; active enantiomer of (±)-7-hydroxy-DPAT.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Photosensitive

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R J Baldessarini et al.
European journal of pharmacology, 239(1-3), 269-270 (1993-08-03)
Racemic 7-hydroxy-N,N-dipropylaminotetralin (7-OH-DPAT) shows greater affinity for limbic-selective dopamine D3 receptors than for more ubiquitous dopamine D2 receptors. R(+)-7-OH-DPAT was prepared and evaluated in radioreceptor assays using membranes of fibroblasts expressing the human dopamine D3 receptor as well as rat
Eriko Ikeda et al.
Molecular pharmacology, 83(5), 959-967 (2013-02-23)
The dopamine D3 receptor (DRD3) in the ventral striatum is thought to influence motivation and motor functions. Although the expression of DRD3 in the ventral striatum has been shown to exhibit 24-hour variations, the mechanisms underlying the variation remain obscure.
P Clément et al.
British journal of pharmacology, 154(5), 1150-1159 (2008-05-13)
The involvement of the neuropeptide oxytocin in the control of male sexual responses is documented although its exact mechanisms of action, and especially the site(s) of action, are not fully delineated. In order to clarify this issue, we tested the
Claudio Bucolo et al.
Biochemical pharmacology, 83(5), 680-686 (2011-12-20)
The aim of the present study was to investigate the role of D₃ receptor on intraocular pressure regulation using WT and KO D₃R⁻/⁻ mice. Both mice were used with normal eye pressure or steroid-induced ocular hypertension. As measured by tonometry
Susanne Koschatzky et al.
ChemMedChem, 7(3), 509-514 (2012-01-04)
The neuromodulatory peptide neurotensin has been described to functionally interact with dopaminergic pathways of the human brain. We employed radioligand binding studies to investigate the physical interaction between co-expressed dopamine D(2L) or D₃ and neurotensin NTS₁ or NTS₂ receptors. Substantial
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