GW21285B

Anti-AXO antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Axotrophin variant
• UNSPSC Code: 12352203

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• manufacturer/tradename: Genway 15-288-21285B
• technique(s): western blot: suitable
• NCBI accession no.: NP_073737.1
• UniProt accession no.: Q53GQ1
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MARCH7(64844)

Description

Immunogen

Immunogen Sequence: GI # 12383066, sequence 481-680

Recombinant axotrophin

Application

Anti-AXO antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

E3 ubiquitin-protein ligase MARCH7 (axotrophin) is an enzyme encoded by the MARCH7 gene in humans and belongs to the MARCH family of proteins. It is a novel family of transmembrane ubiquitin ligases that target glycoproteins for lysosomal destruction via ubiquitination of the cytoplasmic tail. MARCH-7 was first identified in mouse embryonic stem cells as a neural stem cell gene. It has a distinct expression profile from that of other MARCH family members.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves