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D0400

Sigma-Aldrich

9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F2α

Synonym(s):

U44069

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About This Item

Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
56985-32-1
Molecular Weight:
350.49
MDL number:
MFCD00135237
UNSPSC Code:
12352211
PubChem Substance ID:
24893231
NACRES:
NA.77

description

solution in methyl acetate

form

liquid

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCC[C@H](O)\C=C\[C@H]1[C@@H]2CO[C@@H](C2)[C@@H]1C\C=C/CCCC(O)=O

InChI

1S/C21H34O4/c1-2-3-6-9-17(22)12-13-18-16-14-20(25-15-16)19(18)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17-,18-,19+,20-/m0/s1

InChI key

DJKDIKIDYDXHDD-IGUVKOCZSA-N

Biochem/physiol Actions

Prostaglandin F2α analogue; thromboxane A2/prostaglandin H2 mimetic.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H319,H336

Precautionary Statements

P210 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

8.6 °F

Flash Point(C)

-13 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J A Scott et al.
Canadian journal of physiology and pharmacology, 77(2), 89-95 (1999-10-27)
Nonadrenergic noncholinergic (NANC) mediated vasodilation may contribute to the maintenance of low pulmonary vascular tone. The NANC neurotransmitters, nitric oxide (NO) and the sensory neuropeptides, substance P and calcitonin gene related peptide (CGRP), were investigated as possible mediators of NANC
R Scotland et al.
British journal of pharmacology, 128(6), 1229-1234 (1999-12-01)
1 The walls of certain large blood vessels are nourished by the vasa vasorum, a network of microvessels that penetrate the adventitia and media of the vessel wall. The purpose of this study was to characterize endothelin-1 (ET-1)-mediated contraction of
M E Chapman et al.
Poultry science, 85(4), 777-786 (2006-04-18)
The pathogenesis of pulmonary hypertension remains incompletely understood. Many factors have been implicated; however, there has been great interest in the potent pulmonary vasoconstrictor serotonin (5-HT) due to episodes of primary pulmonary hypertension in humans triggered by serotoninergic appetite-suppressant drugs.
K R Olson et al.
The Journal of experimental zoology, 286(6), 606-614 (2000-04-15)
Isolated vessels from four elasmobranchs, yellow stingray (Urolophus jamaicensis), clearnose skate (Raja eglanteria), ghost shark (Hydrolagus novaezelandiae), and spiny dogfish (Squalus acanthias), were examined for the presence of spontaneous contractions (SC). SC were observed in otherwise unstimulated dorsal aortas (DA)
S M Dyer et al.
Clinical and experimental pharmacology & physiology, 25(3-4), 246-251 (1998-05-20)
1. 5-Hydroxytryptamine (5-HT) exerts both contractile and relaxant effects in the marmoset isolated aorta, actions that are unaffected by the 5-HT2 antagonist ketanserin. The aim of the present study was to define the receptors mediating the contractile activity of 5-HT
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