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B1636
Pentagastrin
≥95% (HPLC), powder, CCK2 receptor agonist
Synonym(s):
Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
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25 MG
€207.00
100 MG
€687.00
About This Item
Empirical Formula (Hill Notation):
C37H49N7O9S
CAS Number:
Molecular Weight:
767.89
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Pentagastrin, ≥95% (HPLC), powder
Quality Level
Assay
≥95% (HPLC)
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
DMF: 20 mg/mL, clear, colorless to faint yellow or tan
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
InChI
1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
InChI key
NEYNJQRKHLUJRU-UHFFFAOYSA-N
Gene Information
mouse ... Cckbr(12426)
rat ... Cckar(24889) , Cckbr(25706)
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Amino Acid Sequence
Boc-Bal-Trp-Met-Asp-Phe-NH2
General description
Research area: Immunology & cytokines
Application
Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity.[1] It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[2]
Biochem/physiol Actions
Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin.[3] It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[4] Pentagastrin stimulates the secretion of pepsin and gastric acid.[3] It also aids in the evaluation of gastric acid secretory function.[5] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[4]
antibody
inhibitor
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
Pentagastrin as a stimulant in routine clinical testing of gastric acid secretion.
S A Pedersen
Digestion, 3(2), 81-89 (1970-01-01)
Anton A Hörmann et al.
Pharmaceuticals (Basel, Switzerland), 14(6) (2021-07-03)
The new minigastrin analog DOTA-MGS5 is a promising new candidate for targeting cholecystokinin-2 receptor (CCK2R)-expressing tumors. To enable the clinical translation of PET/CT imaging using 68Ga-labeled DOTA-MGS5, different quality and safety aspects need to be considered to comply with the
Géraldine Pina et al.
Clinical endocrinology, 78(3), 358-364 (2012-08-24)
To evaluate a second-generation assay for basal serum calcitonin (CT) measurements compared with the pentagastrin-stimulation test for the diagnosis of inherited medullary thyroid carcinoma (MTC) and the follow-up of patients with MTC after surgery. Recent American Thyroid Association recommendations suggest
Gilbert H Daniels
Thyroid : official journal of the American Thyroid Association, 21(11), 1199-1207 (2011-09-23)
Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy with the potential for aggressive behavior. Measurement of serum calcitonin (Ct) in the thyroid nodule population is the most sensitive way to detect occult MTC. An important and controversial question is
Functional, Diagnostic and Therapeutic Aspects of Gastrointestinal Hormones
Ahmed M and Ahmed S
Gastroenterology Research and Practice, 233-244 (2019)
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What is the shelf-life of Pentagastrin, Product B1636?
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How can Pentagastrin, Product B1636, solutions be stored?
1 answer-
Pentagastrin is subject to oxidation in solution. A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.
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What is Pentagastrin, Product B1636, soluble in?
1 answer-
Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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