89517
(S)-3,4-Dihydroxybutyric acid lithium salt hydrate
≥95.0% (GC)
Synonym(s):
(S)-3,4-Dihydroxybutanoic acid lithium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C4H8O4 · xLi+ · yH2O
CAS Number:
Molecular Weight:
120.10 (free acid basis)
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
Assay
≥85% (free acid, qNMR)
≥95.0% (GC)
form
solid
optical activity
[α]/D -25±5°, 24 hr, c = 0.1 in 0.1 M HCl
storage temp.
−20°C
SMILES string
O[C@H](CO)CC(O)=O
InChI
1S/C4H8O4/c5-2-3(6)1-4(7)8/h3,5-6H,1-2H2,(H,7,8)/t3-/m0/s1
InChI key
DZAIOXUZHHTJKN-VKHMYHEASA-N
Biochem/physiol Actions
3,4-Dihydroxybutyric acid is a normal human urinary metabolite that is excreted in increased concentration in patients with succinic semialdehyde dehydro- genase (SSADH) deficiency, while healthy adults excrete 0.37 +/- 0.15 (SD) mmoles of 3,4- dihydroxybutyrate per 24 hr. The renal clearance of this compound is roughly equal that of creatinine. This metabolite is also detectable in blood.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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Antonio Noto et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 27 Suppl 2, 46-52 (2014-10-07)
A supervised multivariate model to classify the metabolome alterations between autistic spectrum disorders (ASD) patients and controls, siblings of autistic patients, has been realized and used to realize a network model of the ASD patients' metabolome. In our experiment we
Toshihiro Shinka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 776(1), 57-63 (2002-07-20)
We describe the rapid and sensitive detection of 4-hydroxybutyric acid, which is a marker compound for succinic semialdehyde dehydrogenase (SSADH) deficiency. Urinary 4-hydroxybutyric acid and 3,4-dihydroxybutyric acid were targeted, quantified by gas chromatography-mass spectrometry after simplified urease digestion in which
Moto-o Nakajima et al.
Rinsho byori. The Japanese journal of clinical pathology, 50(5), 513-518 (2002-06-25)
Urinary free ATP assay by the firefly luciferin-luciferase method is a rapid and simple method for determining renal function, especially uriniferous tubule function. Normal range of urinary free ATP concentration, daily ATP excretion in urine, urinary ATP/creatinine value and ATP
The occurrence of (S)-3,4-dihydroxybutyrate in human blood and urine.
V Fell et al.
Biochemical medicine, 13(1), 40-45 (1975-05-01)
Chie Ohdoi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 792(1), 123-130 (2003-06-28)
Lesch-Nyhan syndrome (LNS) is caused by a severe deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) and clinically characterized by self-injurious behavior and nephrolithiasis; the latter is treatable with allopurinol, an inhibitor of xanthine oxidase which converts xanthine and hypoxanthine into uric acid.
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