Cell Marque IVD antibodies are only tested for use on human tissue in a clinical setting with immunohistochemistry only. No other methods such as Fluorescence or Flow Cytometry or western blot or other species such as mouse, rabbit, monkey, etc. have been qualified to work with those antibodies.
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1 ML
€142.00
0.1 ML
€189.00
0.5 ML
€411.00
1 ML
€614.00
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1 ML
€142.00
0.1 ML
€189.00
0.5 ML
€411.00
1 ML
€614.00
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
100
500
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
2F83, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (405M-14)
vial of 0.5 mL concentrate (405M-15)
bottle of 1.0 mL predilute (405M-17)
vial of 1.0 mL concentrate (405M-16)
bottle of 7.0 mL predilute (405M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1κ
control
breast carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... FOXA1(3169)
General description
Forkhead box A1 (FOXA1), also known as hepatocyte nuclear factor 3 alpha(HNF3a), is a transcription factor expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. It has been reported to co-express with ER in breast carcinoma, predominantly in luminal subtype A.[1][2] FOXA1 expression has been identified in 42% - 75% of invasive carcinoma of the breast.[1][2] Of the FOXA1-positive breast invasive carcinomas, 83% were comprised of ER+/PR+/Her2+ luminal A subtype.[1] The results indicate that anti-FOXA1 is useful in the sub-classification of breast carcinoma.
Quality
 IVD |  IVD |  IVD |  RUO |
Linkage
FOXA1 Positive Control Slides, Product No. 405S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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M A Thorat et al.
Journal of clinical pathology, 61(3), 327-332 (2007-11-27)
Forkhead box A1 (FOXA1) is a forkhead family transcription factor expressed in breast cancer cells. It is essential for optimal expression of approximately 50% of oestrogen receptor (ER)-related genes. This study explored the FOXA1 relationship with luminal and basal breast
André Albergaria et al.
Breast cancer research : BCR, 11(3), R40-R40 (2009-06-25)
The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association
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Does the FOXA1 (2F83) antibody only react to human cells, or does it also react to mouse cells?
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