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Sigma-Aldrich

Diethylene glycol monoethyl ether

ReagentPlus®, 99%

Synonym(s):

2-(2-Ethoxyethoxy)ethanol, CARBITOL, Diethylene glycol ethyl ether, Ethyldiglycol

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About This Item

Linear Formula:
C2H5OCH2CH2OCH2CH2OH
CAS Number:
Molecular Weight:
134.17
Beilstein:
1736441
EC Number:
MDL number:
UNSPSC Code:
12352112
PubChem Substance ID:
NACRES:
NA.21

vapor density

4.63 (vs air)

vapor pressure

0.12 mmHg ( 20 °C)

product line

ReagentPlus®

Assay

99%

form

liquid

expl. lim.

1.2 %, 135 °F
23.5 %, 182 °F

refractive index

n20/D 1.427 (lit.)

bp

202 °C (lit.)

mp

-80 °C

solubility

water: soluble

density

0.999 g/mL at 25 °C (lit.)

SMILES string

CCOCCOCCO

InChI

1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3

InChI key

XXJWXESWEXIICW-UHFFFAOYSA-N

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General description

Diethylene glycol monoethyl ether (DEGMEE) is an organic solvent commonly used in the cosmetic industry. Its toxicity has been assessed. Various thermodynamic and optical parameters of an aqueous solution of DEGMEE have been determined. Its quantification along with diethylene glycol (DEG) and coumarin in food samples by gas chromatography-flame ionization technique has been reported.

Application


  • A cautionary note on the effects of laboratory air contaminants on ambient ionization mass spectrometry measurements.: Highlights the influence of diethylene glycol monoethyl ether as a common laboratory contaminant that can affect the accuracy of mass spectrometry analyses, underscoring the importance of controlling environmental variables in high-precision analytical settings (Kumbhani SR et al., 2017).

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
CARBITOL is a trademark of The Dow Chemical Company or an affiliated company of Dow

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

204.8 °F - closed cup

Flash Point(C)

96 °C - closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous determination of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food items by gas chromatography.
Rahim AA, et al.
Food Chemistry, 126(3), 1412-1416 (2011)
Reproductive toxicology. Diethylene glycol monoethyl ether.
Environmental health perspectives, 105 Suppl 1, 209-210 (1997-02-01)
Thermodynamic and optical studies of some ethylene glycol ethers in aqueous solutions at T = 298.15 K.
Dhondge SS, et al.
The Journal of Chemical Thermodynamics, 41(5), 577-585 (2009)
Maria Manconi et al.
International journal of pharmaceutics, 412(1-2), 37-46 (2011-05-03)
The ability of a recently developed novel class of liposomes to promote dermal delivery of tretinoin (TRA) was evaluated. New penetration enhancer-containing vesicles (PEVs) were prepared adding to conventional phosphatidylcholine vesicles (control liposomes) different hydrophilic penetration enhancers: Oramix NS10 (OrNS10)
Jeoung Hee Yoo et al.
Archives of pharmacal research, 33(3), 417-426 (2010-04-03)
Self-nanoemulsifying drug delivery system (SNEDDS) containing oil (Phosal 53 MCT), surfactant (Labrasol), and cosurfactant (Transcutol-HP or Lutrol-E400) was prepared to enhance solubility and dissolution of lutein. Ternary phase diagram of the SNEDDS was constructed to identify the self-emulsifying regions following

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