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D4285

Supelco

(±)-Dropropizine

analytical standard, for drug analysis

Synonym(s):

3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

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About This Item

Empirical Formula (Hill Notation):
C13H20N2O2
CAS Number:
17692-31-8
Molecular Weight:
236.31
EC Number:
241-683-7
MDL number:
MFCD00079124
UNSPSC Code:
41116107
PubChem Substance ID:
329798797
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OCC(O)CN1CCN(CC1)c2ccccc2

InChI

1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2

InChI key

PTVWPYVOOKLBCG-UHFFFAOYSA-N

General description

(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.

Application

(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
018F0335

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Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe M M, et al.
Enzyme and Microbial Technology, 28(4-5), 333-338 (2001)
Lin Yan et al.
Archives of pharmacal research, 29(6), 514-519 (2006-07-13)
A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) in dog plasma. The sample was prepared for injection using a liquid-liquid extraction method with 1-phenypiperazine as the internal standard. The mobile phase
Li-mei Zhao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(12), 993-996 (2005-04-09)
To develop a rapid and sensitive LC/MS/MS method for the analysis of levodropropizine in plasma and study the pharmacokinetics of levodropropizine in healthy Chinese volunteers. Levodropropizine and zolmitriptan (internal standard, IS) were extracted from plasma samples and chromatographed on a
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