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A115

Supelco

Amitriptyline metabolite, (±)-E-10-hydroxylated-

analytical standard

Synonym(s):

(±)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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2 MG
€149.00

€149.00

List Price€298.00Save 50%

Estimated to ship onMay 28, 2025

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2 MG
€149.00

About This Item

Empirical Formula (Hill Notation):
C20H23NO
CAS Number:
64520-05-4
Molecular Weight:
293.40
MDL number:
MFCD00069200
UNSPSC Code:
41116107
PubChem Substance ID:
329770681
NACRES:
NA.24

€149.00

List Price€298.00Save 50%

Estimated to ship onMay 28, 2025

Request a Bulk Order

grade

analytical standard

Quality Level

200

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

mp

97-99 °C

solubility

0.1 M HCl: soluble
H2O: insoluble
methanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

InChI key

GHWBJXOKAFHZAI-SFQUDFHCSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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X H Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 28(2), 85-91 (1993-01-01)
The demethylation and hydroxylation of amitriptyline were calculated from the ratios between the area under concentration--time curve (AUC) of amitriptyline and its three metabolites in eight healthy Chinese volunteers after a single oral dose of 100 mg amitriptyline. Great interindividual
K Shimoda et al.
Journal of clinical psychopharmacology, 15(3), 175-181 (1995-06-01)
We measured the concentrations in plasma of amitriptyline and its metabolites, nortriptyline and geometric isomers of 10-hydroxynortriptyline and 10-hydroxyamitriptyline, in 73 Japanese psychiatric patients receiving amitriptyline hydrochloride (Tryptanol; Banyu Pharmaceutical Co. Ltd., Tokyo, Japan) by high-performance liquid chromatography. Although there
F Coudoré et al.
Cell biology and toxicology, 13(2), 131-137 (1997-02-01)
Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of the diabetic state. Levels of free and conjugated AMI, demethylated and hydroxylated metabolites, were
Determination of tricyclic antidepressants in body fluids and organ material by HPLC.
Wedy, et al.
Fresenius Journal of Analytical Chemistry, 332, 266-266 (1988)
D R Jones et al.
Journal of chromatography, 278(2), 291-299 (1983-12-09)
A selective, sensitive method for the determination of amitriptyline and its metabolites is described. This method involves liquid-liquid extraction and capillary gas chromatography with nitrogen-sensitive detection. The detection limits of amitriptyline, nortriptyline, 10-hydroxy(E)amitriptyline, 10-hydroxy(E)nortriptyline, and 10-hydroxy(Z)nortriptyline were slightly less than
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