The American review of respiratory disease, 144(3 Pt 1), 649-654 (1991-09-01)
How variable is the deposition of inhaled methacholine (MCH) in the respiratory tract during a challenge test? Does this variability contribute to the variability of airway responsiveness? To examine these questions we estimated the deposition of polydisperse MCH droplets by
Laser ablation inductively coupled plasma mass spectrometry was used to evaluate ion depth profiles across ion-selective membranes. Advantageously, this approach does not require incorporation of additional components (e.g., chromoionophore) in the membrane composition, as compared to that used in typical
Theoretical models of particle deposition in the respiratory tract predict high fractional deposition for particles of less than 0.1 micron, but there are few confirming experimental data for those predictions. We have measured the deposition fraction of a nonhygroscopic aerosol
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