A series of N-(2-hydroxy-3-sulfonamidobenzene)-N'-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.
Archiv der Pharmazie, 344(12), 775-785 (2011-10-12)
Recently, we identified highly potent agonists of the human histamine H(4) receptor (hH(4) R) among a series of imidazolylbutylcyanoguanidines. Aiming at improved selectivity for the hH(4) R relative to the H(3) receptor (hH(3) R), the flexible tetramethylene linker connecting imidazole
Expert opinion on investigational drugs, 16(7), 999-1007 (2007-06-28)
'Overactive bladder' (OAB) is a syndrome that is characterised by symptoms of urgency, with or without urge urinary incontinence, usually with frequency and nocturia [1] . It is a highly prevalent condition affecting 17% of the general population, with a
Increasing evidence demonstrated the involvement of ammonia-oxidizing archaea (AOA) in the global nitrogen cycle, but the relative contributions of AOA and ammonia-oxidizing bacteria (AOB) to ammonia oxidation are still in debate. Previous studies suggest that AOA would be more adapted
A field experiment was conducted to study the effect of timing of joint application of urease inhibitor hydroquinone (HQ) and nitrification inhibitor dicyandiamide (DCD) on N(2)O emission from irrigated lowland rice paddy field. Four treatments including Treatment CK (the control
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