911690

C5 Lenalidomide

≥95%

• Synonym(s): 3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC^® research
• Empirical Formula (Hill Notation): C₁₃H₁₃N₃O₃
• CAS Number: 191732-70-4
• Molecular Weight: 259.26
• MDL number: MFCD31692701
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• ligand: C5 Lenalidomide
• Quality Level: 100
• Assay: ≥95%
• form: powder
• reaction suitability: reagent type: ligand
• storage temp.: 2-8°C
• SMILES string: NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1
• InChI: 1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)
• InChI key: WLUIQUZGNPAKRL-UHFFFAOYSA-N

Description

Application

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H361d,H373
• Precautionary Statements: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Target Organs: Blood
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable