774642

(Diethylamino)sulfur trifluoride solution

1.0 M in dichloromethane

• Synonym(s): DAST solution in dichloromethane
• Empirical Formula (Hill Notation): C₄H₁₀F₃NS
• CAS Number: 38078-09-0
• Molecular Weight: 161.19
• MDL number: MFCD00000363
• UNSPSC Code: 12352101
• PubChem Substance ID: 329767703
• NACRES: NA.22

Properties

• form: liquid
• concentration: 1.0 M in dichloromethane
• density: 1.303 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: CCN(CC)S(F)(F)F
• InChI: 1S/C4H10F3NS/c1-3-8(4-2)9(5,6)7/h3-4H2,1-2H3
• InChI key: CSJLBAMHHLJAAS-UHFFFAOYSA-N

Description

Application

• Fluorinating agent: reaction with alcohols and carbonyl compounds, Review
• Review on nucleophilic fluorination.
• Catalyst for Friedel-Crafts allylation using tertiary cyclopropyl silyl ethers and the rearrangement of homoallylic alcohols to unsaturated aldehydes.
• Early introduction of a fluoromethyl group stabilizes the epoxide during further manipulations in the synthesis of 26-fluoro-epothilone.
• Fluorinating agent for a variety of compounds, including thioethers, alkenols, and cyanohydrins.
• Reagent for gem difluorination of ketopipecolinic acids.

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H226,H314,H336,H351
• Precautionary Statements: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Carc. 2 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A - STOT SE 3
• Target Organs: Central nervous system
• Supplementary Hazards: EUH014
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 75.2 °F
• Flash Point(C): 24 °C