Skip to Content
Merck
All Photos(1)

Documents

279072

Sigma-Aldrich

Cyproheptadine hydrochloride sesquihydrate

99%

Synonym(s):

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine hydrochloride hydrate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H21N · HCl · 1.5H2O
CAS Number:
41354-29-4
Molecular Weight:
350.88
EC Number:
213-535-1
UNSPSC Code:
12352100
PubChem Substance ID:
24856848
NACRES:
NA.22

Assay

99%

form

solid

mp

165 °C (dec.) (lit.)

solubility

1 M NH4OH: soluble 25 mg/mL, clear, colorless to faintly yellow

SMILES string

O.O.O.Cl.CN1CCC(\CC1)=C2\c3ccccc3C=Cc4ccccc24.CN5CCC(\CC5)=C6\c7ccccc7C=Cc8ccccc68

InChI

1S/2C21H21N.ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;/h2*2-11H,12-15H2,1H3;1H;3*1H2

InChI key

PXCSXCDWTUPVIM-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine. It induced preventive effect against the development of pergolide-induced valvulopathy in a rat model.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The structure of an antihistamine: cyproheptadine hydrochloride sesquihydrate.
Birknes BJORN.
Acta Crystallographica Section B, Structural Science, 33(3), 687-691 (1977)
Steven Droogmans et al.
American journal of physiology. Heart and circulatory physiology, 296(6), H1940-H1948 (2009-04-07)
Serotonergic drugs, such as pergolide, have been associated with the development of cardiac valvular myxoid thickening and regurgitation in humans and more recently in rats. These effects are potentially mediated by the 5-hydroxytryptamine (5-HT)(2B) receptor (5-HT(2B)R). Therefore, we sought to
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service