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264415

Sigma-Aldrich

2,4-Difluorobenzyl bromide

98%

Synonym(s):

α-Bromo-2,4-difluorotoluene

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About This Item

Linear Formula:
F2C6H3CH2Br
CAS Number:
23915-07-3
Molecular Weight:
207.02
EC Number:
245-938-3
MDL number:
MFCD00011649
UNSPSC Code:
12352100
PubChem Substance ID:
24856014
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.525 (lit.)

density

1.613 g/mL at 25 °C (lit.)

SMILES string

Fc1ccc(CBr)c(F)c1

InChI

1S/C7H5BrF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2

InChI key

IBLMYGXJKQIGSN-UHFFFAOYSA-N

Application

2,4-Difluorobenzyl bromide has been used in the preparation of:
  • novel 1,2,4-triazolium derivatives
  • 1,5-biaryl pyrrole EP1 receptor antagonists

Signal Word

Danger

Hazard Statements

H226,H314,H317,H334

Hazard Classifications

Flam. Liq. 3 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

104.0 °F - closed cup

Flash Point(C)

40 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adrian Hall et al.
Bioorganic & medicinal chemistry letters, 16(14), 3657-3662 (2006-05-16)
The preliminary SAR of a series of novel 1,5-biaryl pyrrole EP1 receptor antagonists derived from compound 1 is described. Replacement of the benzyl group of 1 with isosteric groups was investigated. The most effective replacement was found to be the
Yan Luo et al.
Archiv der Pharmazie, 342(7), 386-393 (2009-06-23)
A series of novel 1,2,4-triazolium derivatives was synthesized starting from commercially available 1H-1,2,4-triazole, 2,4-dichlorobenzyl chloride, or 2,4-difluorobenzyl bromide. Their antibacterial and antifungal activities were evaluated against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Bacillus proteus, Bacillus subtilis, Pseudomonas aeruginosa

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