219835
2-Hydroxy-3-methylbutyric acid
99%
Synonym(s):
2-Hydroxyisovaleric acid
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About This Item
Linear Formula:
(CH3)2CHCH(OH)CO2H
CAS Number:
Molecular Weight:
118.13
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
99%
form
solid
mp
86-87 °C (lit.)
SMILES string
CC(C)C(O)C(O)=O
InChI
1S/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)
InChI key
NGEWQZIDQIYUNV-UHFFFAOYSA-N
Related Categories
General description
Chiral resolution of 2-hydroxy-3-methylbutyric acid without derivatization has been studied by capillary electrophoresis using 2-hydroxypropyl-β-cyclodextrin.
Application
2-Hydroxy-3-methylbutyric acid was employed as internal standard for analysis of ethylene glycol (EG) and γ-hydroxybutyrate (GHB) in whole blood.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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F Magni et al.
Analytical biochemistry, 220(2), 308-314 (1994-08-01)
A sensitive method for the simultaneous analysis of plasma alpha-ketoisocaproic acid (KIC) and leucine using GC-MS is described. Plasma was deproteinized after addition of both alpha-ketovaleric acid and norleucine as internal standards. Derivatization of the compounds involved protection of the
S Landaas et al.
Clinica chimica acta; international journal of clinical chemistry, 78(3), 489-493 (1977-08-01)
Examination of urine samples by capillary column gas chromatography and mass spectrometry showed the presence of 2-hydroxyisovaleric acid together with trace amounts of the three branched-chain 2-keto acids in five patients with lactic and ketoacidosis. None of these compounds was
Y M Pan et al.
Journal of analytical toxicology, 25(5), 328-332 (2001-08-14)
The modification of a procedure originally developed for the analysis of ethylene glycol (EG) in serum was also found to permit the simultaneous analysis of gamma-hydroxybutyrate (GHB) in whole blood. The primary feature of the EG procedure was that it
Direct chiral resolution of aliphatic a-hydroxy acids using 2-hydroxypropyl-?-cyclodextrin in capillary electrophoresis.
Kodama S, et al.
Analyst, 124(1), 55-59 (1999)
H M Liebich et al.
Journal of chromatography, 309(2), 225-242 (1984-08-10)
Hydroxy- and oxomonocarboxylic acids in urine of healthy individuals and of patients with diabetic ketoacidosis are analysed as methyl esters and methyl esters/O-methyloximes, respectively, by gas chromatography and gas chromatography-mass spectrometry. The derivatives are pre-fractionated by thin-layer chromatography. The acids
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