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143456

Sigma-Aldrich

2-Amino-5-chlorothiazole hydrochloride

95%

Synonym(s):

(5-Chlorothiazol-2-yl)amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C3H3ClN2S · HCl
CAS Number:
55506-37-1
Molecular Weight:
171.05
EC Number:
259-680-4
MDL number:
MFCD00039006
UNSPSC Code:
12352100
PubChem Substance ID:
24848586
NACRES:
NA.22

Assay

95%

mp

164-167 °C (dec.) (lit.)

SMILES string

Cl[H].Nc1ncc(Cl)s1

InChI

1S/C3H3ClN2S.ClH/c4-2-1-6-3(5)7-2;/h1H,(H2,5,6);1H

InChI key

GTMGFQYVLSQTKP-UHFFFAOYSA-N

Related Categories

Application

2-Amino-5-chlorothiazole hydrochloride was used as starting reagent in the synthesis of 2-chloro-6-methylimidazo[2,1-b]thiazole.
  • Reactant for preparation of biologically active thiazole derivatives

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H317,H318,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Aldo Andreani et al.
Bioorganic & medicinal chemistry, 12(21), 5525-5532 (2004-10-07)
In this work we describe the synthesis of a series of imidazo[2,1-b]thiazoles and 2,3-dihydroimidazo[2,1-b]thiazoles connected by means of a methylene bridge to CoQ(0). These compounds were tested as specific inhibitors of the NADH:ubiquinone reductase activity in mitochondrial membranes. The imidazothiazole

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