Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

108596

Sigma-Aldrich

3-Chloro-6-methoxypyridazine

95%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C5H5ClN2O
CAS Number:
1722-10-7
Molecular Weight:
144.56
EC Number:
217-019-7
MDL number:
MFCD00006467
UNSPSC Code:
12352100
PubChem Substance ID:
24846813
NACRES:
NA.22

Assay

95%

mp

84-85 °C (lit.)

SMILES string

COc1ccc(Cl)nn1

InChI

1S/C5H5ClN2O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3

InChI key

XBJLKXOOHLLTPG-UHFFFAOYSA-N

General description

3-Chloro-6-methoxypyridazine undergoes regioselective metallation using various lithium alkylamides, temperatures and solvents (THF and ether). It was lithiated using lithium 2,2,6,6-tetramethylpiperidide during the synthesis of minaprine.

Application

3-Chloro-6-methoxypyridazine was used in the preparation of number of α-aryl-α-(pyridazin-3-yl)-acetonitriles.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Advances in the directed metallation of azines and diazines (pyridines, pyrimidines, pyrazines, pyridazines, quinolines, benzodiazines and carbolines). Part 2: Metallation of pyrimidines, pyrazines, pyridazines and benzodiazines.
Turck A, et al.
Tetrahedron, 57(21), 4489-4505 (2001)
Franciszek Herold et al.
Molecules (Basel, Switzerland), 12(12), 2643-2657 (2008-02-09)
This paper describes a modified method of preparation of a number of alpha-aryl-alpha-(pyridazin-3-yl)-acetonitriles via the C-arylation reaction of the corresponding carbanionsof phenylacetonitriles using 3-chloropyridazine derivatives. KOH and DMSO were used inthe deprotonation process, which made the reaction very simple and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service