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Key Documents

SML3842

Sigma-Aldrich

TAT-SAMβA trifluoroacetate

≥95% (HPLC)

Synonym(s):

SAMβA trifluoroacetate, TAT(47-57)-GG-βIIPKC(624-632) trifluoroacetate, TAT(47-57)-GG-SAMβA trifluoroacetate, YGRKKRRQRRR-GG-RNAENFDRF trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C118H195N51O31 · xC2HF3O2
Molecular Weight:
2824.13 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

Biochem/physiol Actions

TAT-SAMβA is a mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1. TAT-SAMβA protects neonatal and adult rat cardiac myocytes, but not Mfn1-knockout cells, from stress-induced death in cultures and improves cardiac contractility in rats with heart failure in vivo (3 mg/kg/day for 6 wks via Alzet pump delivery) by re-establishing mitochondrial morphology and function. TAT-SAMβA is composed of a 9-aa βIIPKC-derived MFN1-interacting sequence linked at the N-terminal to the cell permeable TAT(47-57) via a -Gly-Gly- spacer

Caution

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A selective inhibitor of mitofusin 1-?IIPKC association improves heart failure outcome in rats
Nature Communications, 10(1), 329-329 (2019)
The Mfn1-?IIPKC Interaction Regulates Mitochondrial Dysfunction via Sirt3 Following Experimental Subarachnoid Hemorrhage
Translational Stroke Research, 13(5), 845-857 (2022)

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