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SCP0118

Sigma-Aldrich

[Tyr0]-C-Peptide / Proinsulin (32-63) Tyr0

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C138H220N36O50
Molecular Weight:
3183.43
UNSPSC Code:
12352209
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Tyr-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln

Application

C-Peptide acts via GPCRs to activate Ca2+-dependent intracellular signaling pathways such as MAPK, PLCgamma, and PKC leading to upregulation of a range of transcription factors as well as eNOS and Na+/K+ATPase activities.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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What's new in diabetes: incretins and C-peptide.
Vincent Marks
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 20(2), 101-102 (2011-01-22)
C-peptide and long-term complications of diabetes.
Patrizia Luppi et al.
Pediatric diabetes, 12(3 Pt 2), 276-292 (2010-12-07)
Claire E Hills et al.
American journal of nephrology, 31(5), 389-397 (2010-04-02)
Insulin is synthesised as a pro-hormone with an interconnecting C-peptide, cleaved during post-translational modification. This review discusses growing evidence which indicates that C-peptide is biologically active, benefiting microvascular complications associated with diabetes. To explore the renoprotective role of C-peptide in
Pro-insulin, C peptide, glucagon, adiponectin, TNF α, AMPK: neglected players in type 2 diabetes mellitus.
Lele RD.
The Journal of the Association of Physicians of India, 58, 35-40 (2010)

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