Skip to Content
Merck
All Photos(1)

Key Documents

SAE0112

Sigma-Aldrich

β2-Microglobulin from human urine

≥98% (SDS-PAGE), solution

Synonym(s):

β2-Microglobulin from human urine

Sign Into View Organizational & Contract Pricing


About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Assay

≥98% (SDS-PAGE)

form

solution

impurities

Infectious Agents, tested

solubility

water: soluble

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... B2M(567)

Looking for similar products? Visit Product Comparison Guide

General description

Research area: Cancer

β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. It is a non-glycosylated protein, synthesized by all nucleated cells. Its secondary structure comprises of seven β-strands, arranged into two β-sheets connected by a single disulfide bridge.

Application

β2-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

Biochem/physiol Actions

The interaction of β2 microglobulin (β2-M) with major histocompatibility complex (MHC) is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome. β2-M serves as a regulator of cell survival, proliferation, migration, invasion, apoptosis, angiogenesis, and metastasis in cancer cells. It is also recognized for promoting the growth and survival of stromal cells, such as mesenchymal stem cells (MSCs), osteoblasts, and osteoclasts, thereby supporting cancer bone metastasis.

Preparation Note

Prepared by the method of Berggard and Bearn.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

?2-Microglobulin: emerging as a promising cancer therapeutic target
Shi C, et al.
Drug Discovery Today, 14(1-2), 25-30 (2009)
The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator
Li L, et al.
Chinese Medical Journal (English Edition), 129(4), 448-455 (2016)
?2-Microglobulin-mediated Signaling as a Target for Cancer Therapy
Nomura T, et al.
Anticancer Agents in Medicinal Chemistry, 14(3), 343?352-343?352 (2014)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service