P3755

6-Propyl-2-thiouracil

enzyme inhibitor

• Synonym(s): 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine
• Empirical Formula (Hill Notation): C₇H₁₀N₂OS
• CAS Number: 51-52-5
• Molecular Weight: 170.23
• Beilstein: 130039
• EC Number: 200-103-2
• MDL number: MFCD00006041
• UNSPSC Code: 41106305
• PubChem Substance ID: 24898446
• NACRES: NA.51

Properties

• description: enzyme inhibitor
• Quality Level: 200
• Assay: ≥99% (HPLC)
• form: powder
• mp: 218-220 °C (lit.)
• solubility: 10% NH₃: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: CCCC1=CC(=O)NC(=S)N1
• InChI: 1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
• InChI key: KNAHARQHSZJURB-UHFFFAOYSA-N
• Gene Information: human ... DIO1(1733) , TPO(7173)

Description

General description

6-Propyl-2-thiouracil or 6-n-Propylthiouracil (PROP) is a compound with a bitter taste.

Application

6-Propyl-2-thiouracil (PROP) has been used to impregnate on disk for PROP taster status studies for sensory characterization in a defined human sample group. It has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).

6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, high performance liquid chromatography (HPLC), or gas chromatography.

Biochem/physiol Actions

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H351
• Precautionary Statements: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves