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N6413

Sigma-Aldrich

Anti-NR4A2 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-HZF-3, Anti-NOT, Anti-NURR1, Anti-RNR1, Anti-TINUR

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~70 kDa

species reactivity

human, mouse, rat

concentration

~1.5 mg/mL

technique(s)

indirect immunofluorescence: 4-8 μg/mL using 3T3 cells
western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NR4A2(4929)
mouse ... Nr4a2(18227)
rat ... Nr4a2(54278)

Related Categories

General description

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.

Application

Anti-NR4A2 (N-terminal) antibody has been used in
  • immunoblotting
  • immunofluorescence
  • western blotting

Biochem/physiol Actions

NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) as monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, growth factors and neurotransmitters in a cell type specific manner. Hepatic expression of NR4A2 is induced by cAMP in response to glucagon and fasting. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia.
Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.

Target description

NR4A2 (N-terminal) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, includ

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease
Pearen M A and Muscat G E
Molecular Endocrinology, 24(10), 1891-1903 (2010)
Optogenetic inhibitor of the transcription factor CREB
Ali A M, et al.
Chemistry & Biology, 22(11), 1531-1539 (2015)
Enhancing beta-catenin activity via GSK3beta inhibition protects PC12 cells against rotenone toxicity through Nurr1 induction
Zhang L, et al.
PLoS ONE, 11(4), e0152931-e0152931 (2016)
Mutations in NR4A2 associated with familial Parkinson disease
Le W D, et al.
Nature Genetics, 33(1), 85-85 (2002)
Huimin Gao et al.
Scientific reports, 6, 34403-34403 (2016-09-30)
The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted

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