M9005

3-Methyl-L-histidine

≥98% (TLC)

• Synonym(s): π-Methyl-L-histidine, 1-Methyl-L-histidine (archaic), 3-(1-Methylimidazol-5-yl)-L-alanine
• Empirical Formula (Hill Notation): C₇H₁₁N₃O₂
• CAS Number: 368-16-1
• Molecular Weight: 169.18
• EC Number: 206-704-6
• MDL number: MFCD00083658
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24897303
• NACRES: NA.26

Properties

• product name: 3-Methyl-L-histidine,
• Assay: ≥98% (TLC)
• form: powder
• color: white to off-white
• mp: 254 °C
• application(s): detection
• SMILES string: Cn1cncc1C[C@H](N)C(O)=O
• InChI: 1S/C7H11N3O2/c1-10-4-9-3-5(10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1
• InChI key: JDHILDINMRGULE-LURJTMIESA-N

Description

Application

• Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues.: Exploring innovative genetic engineering techniques, this research advances the use of histidine analogues like 3-Methyl-L-histidine for producing novel proteins with enhanced functionalities, offering vast potential in therapeutic and industrial applications (Taylor et al., 2023).


• Improving the enzymatic activity of l-amino acid α-ligase for imidazole dipeptide production by site-directed mutagenesis.: This investigation enhances the enzymatic synthesis of imidazole dipeptides, crucial for understanding the role of modifications like those seen in 3-Methyl-L-histidine and its impact on biological activities (Kino et al., 2023).

Biochem/physiol Actions

3-Methyl-L-histidine is a non-proteinogenic amino acid and an index of muscle breakdown.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves