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Y0000471

Buspirone for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Buspirone hydrochloride, N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H31N5O2 · HCl
CAS Number:
33386-08-2
Molecular Weight:
421.96
MDL number:
MFCD00078569
UNSPSC Code:
41116107
PubChem Substance ID:
329830975
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

buspirone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI key

RICLFGYGYQXUFH-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Buspirone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; anxiolytic.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0000131

Buspirone hydrochloride, European Pharmacopoeia (EP) Reference Standard

1078802

Buspirone hydrochloride, United States Pharmacopeia (USP) Reference Standard

1078573

Buspirone Related Compound A, United States Pharmacopeia (USP) Reference Standard

1078824

Buspirone Related Compound L, United States Pharmacopeia (USP) Reference Standard

1078835

Buspirone Related Compound N, United States Pharmacopeia (USP) Reference Standard

1078813

Buspirone Related Compound G, United States Pharmacopeia (USP) Reference Standard

1078642

Buspirone Related Compound K, United States Pharmacopeia (USP) Reference Standard

PHR1917

Buspirone hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2845

Buspirone Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2846

Buspirone Related Compound G, certified reference material, pharmaceutical secondary standard

PHR2847

Buspirone Related Compound K, pharmaceutical secondary standard, certified reference material

PHR2848

Buspirone Related Compound N

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

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Kah-Chung Leong et al.
Behavioural brain research, 234(2), 299-302 (2012-07-18)
Previous findings indicate that post-training administration of the anxiogenic α(2)-adrenoceptor antagonist RS 79948-197 facilitates the consolidation of dorsal striatal-dependent habit memory. The present study examined the effect of concurrent administration of the anxiolytic serotonin 5-HT(1A) receptor partial agonist buspirone on
Jack Bergman et al.
The international journal of neuropsychopharmacology, 16(2), 445-458 (2012-07-26)
Converging lines of evidence indicate that elevations in synaptic dopamine levels play a pivotal role in the reinforcing effects of cocaine, which are associated with its abuse liability. This evidence has led to the exploration of dopamine receptor blockers as
Feng Qiu et al.
Biomedical chromatography : BMC, 27(2), 233-239 (2012-06-19)
This study firstly describes the development of an accurate and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for the quantification of Taiwanin E methyl ether (TEME) in rat plasma. The assay involved a simple liquid-liquid extraction step with ethyl
Long Yuan et al.
Bioanalysis, 4(23), 2795-2804 (2012-12-12)
A dried blood spot (DBS) bioanalysis assay involves many steps, such as the preparation of standard (STD) and QC samples in blood, the spotting onto DBS cards, and the cutting-out of the spots. These steps are labor intensive and time
C Loane et al.
Brain research, 1461, 111-118 (2012-05-23)
Buspirone is an anxiolytic drug and is a partial agonist for the serotonin 5-HT(1A) receptors as well as possessing low affinity and is an antagonist for the dopamine D(2) autoreceptors, with some evidence of a weak affinity to 5-HT(2) receptors.
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