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Supelco

(−)-Bilobalide

analytical standard

Synonym(s):

Bilobalide

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About This Item

Empirical Formula (Hill Notation):
C15H18O8
CAS Number:
Molecular Weight:
326.30
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥96.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

CC(C)(C)[C@]1(O)C[C@@H]2OC(=O)C[C@]23C(=O)O[C@@H]4OC(=O)[C@H](O)C134

InChI

1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13+,14+,15?/m0/s1

InChI key

MOLPUWBMSBJXER-DXPZGIEZSA-N

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General description

(−)-Bilobalide is a Ginkgo terpenoid, available as the main pharmacological component in Ginkgo biloba extract. It exhibits neuroprotectant activity.

Application

(−)-Bilobalide may be used as an analytical rstandard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: ginkgo

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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LC-ESI-MS determination of bilobalide and ginkgolides in canine plasma
Tang J, et al.
Chromatographia, 63(1-2), 53-58 (2006)
Jiangang Shen et al.
Chinese medicine, 6, 8-8 (2011-02-25)
EGb761 is a standard extract from the leaves of Ginkgo biloba (Yinxing) containing ginkgo-flavone glycosides and terpenoid. The flavonoid components of EGb761 scavenge free radicals and protect myocardia from ischemia-reperfusion injury. The present study aims to determine the effects of
Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats
Xie J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864(1-2), 87-94 (2008)
Etsuko Suzuki et al.
The journal of physiological sciences : JPS, 61(5), 421-427 (2011-06-29)
Bilobalide, a unique constituent of Ginkgo biloba, has been reported to potentiate population spikes in hippocampal CA1 pyramidal cells and to protect the brain against cell death. In this study, the effects of bilobalide on synaptic transmission and its plasticity
Aik Jiang Lau et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(1), 178-186 (2011-10-25)
Bilobalide is a naturally occurring sesquiterpene trilactone with therapeutic potential in the management of ischemia and neurodegenerative diseases such as Alzheimer's disease. In the present study, we investigated the effect of bilobalide on the activity of rat constitutive androstane receptor

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