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890000P

Avanti

MVL5

Avanti Research™ - A Croda Brand 890000P, powder

Synonym(s):

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

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About This Item

Empirical Formula (Hill Notation):
C59H116Cl5N7O4
CAS Number:
464926-03-2
Molecular Weight:
1164.86
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

package of 1 × 1 mg (890000P-1mg)
package of 1 × 5 mg (890000P-5MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890000P

application(s)

advanced drug delivery

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCC/C=C\CCCCCCCCOC1=C(OCCCCCCCC/C=C\CCCCCCCC)C=C(C(NCCNC(C([NH2+]CCC[NH3+])CCC[N+](CCC[NH3+])([H])CCC[NH3+])=O)=O)C=C1.[5Cl-]

Application

MVL5 has been used in liposome preparation.

Biochem/physiol Actions

MVL5 is a cationic lipid and is a pentavalent molecule. It is combined with 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOPC) in liposome formulation, for efficient gene transfection. It is considered less toxic.

Packaging

5 mL Amber Glass Screw Cap Vial (890000P-1MG)
5 mL Amber Glass Screw Cap Vial (890000P-5MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chia-Ling Chan et al.
The journal of gene medicine, 16(3-4), 84-96 (2014-04-23)
Cationic liposome (CL)-DNA complexes are promising gene delivery vectors with potential application in gene therapy. A key challenge in creating CL-DNA complexes for application is that their transfection efficiency (TE) is adversely affected by serum. In particular, little is known
Nathan F Bouxsein et al.
Biochemistry, 46(16), 4785-4792 (2007-03-30)
Small interfering RNAs (siRNAs) of 19-25 bp mediate the cleavage of complementary mRNA, leading to post-transcriptional gene silencing. We examined cationic lipid (CL)-mediated delivery of siRNA into mammalian cells and made comparisons to CL-based DNA delivery. The effect of lipid
Endosomal escape and transfection efficiency of PEGylated cationic liposome-DNA complexes prepared with an acid-labile PEG-lipid
Chan CL, et al.
Biomaterials, 33(19), 4928-4935 (2012)
Cecília Leal et al.
Langmuir : the ACS journal of surfaces and colloids, 27(12), 7691-7697 (2011-05-27)
The self-assembly of a custom-synthesized pentavalent cationic lipid (MVL5) and glycerol monooleate (GMO) with small interfering RNA (siRNA) results in the formation of a double-gyroid bicontinuous inverted cubic phase with colocalized lipid/siRNA domains as shown by synchrotron X-ray scattering and
Polyamine Drug Discovery, 226-226 (2012)
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