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840012P

Avanti

Heart CA

Avanti Research™ - A Croda Brand 840012P, powder

Synonym(s):

Cardiolipin (Heart, Bovine) (sodium salt)

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About This Item

CAS Number:
383907-10-6
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 mg (840012P-100mg)
pkg of 1 × 25 mg (840012P-25mg)
pkg of 1 × 50 mg (840012P-50mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840012P

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O.[Na+].[Na+]

InChI

1S/C81H142O17P2.2Na/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2;;/h21-28,33-40,75-77,82H,5-20,29-32,41-74H2,1-4H3,(H,87,88)(H,89,90);;/q;2*+1/p-2/b25-21-,26-22-,27-23-,28-24-,37-33-,38-34-,39-35-,40-36-;;/t76-,77-;;/m1../s1

InChI key

ZGSPNIOCEDOHGS-LBOJVHLDSA-L

General description

Cardiolipin is a unique phospholipid present in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.

Application

Heart CA has been used as a standard stock solution for its quantitative analysis using liquid chromatography−mass spectrometry (LC-MS)/MS. It has also been used for liposome preparation.

Biochem/physiol Actions

Cardiolipin is involved in the dynamic organization of membranes and in cell division. It is implicated in proton uptake pathway. Cardiolipin plays a vital role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It regulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.

Packaging

5 mL Clear Glass Sealed Ampule (840012P-100mg)
5 mL Clear Glass Sealed Ampule (840012P-25mg)
5 mL Clear Glass Sealed Ampule (840012P-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The role of cardiolipin in cardiovascular health
Shen Z, et al.
BioMed Research International, 2015(1) (2015)
A rapid and sensitive LC-MS/MS method for quantitative analysis of cardiolipin (18: 2) 4 in human leukocytes and mouse skeletal muscles
Xu G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 158(1), 386-394 (2018)
Role of cardiolipin in mitochondrial signaling pathways
Dudek J
Frontiers in Cell and Developmental Biology, 5(1), 90-90 (2017)
Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose
Moore DS and Hand SC
Cryobiology, 73(2), 240-247 (2016)
Hay-Yan J Wang et al.
Journal of the American Society for Mass Spectrometry, 18(3), 567-577 (2006-12-13)
Cardiolipins (CL) are mitochondria specific lipids. They play a critical role in ATP synthesis mediated by oxidative phosphorylation. Abnormal CL distribution is associated with several disease states. MALDI-MS and MALDI-MS/MS were used to demonstrate in situ analysis and characterization of
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