810120P
Avanti
18:0 PEG2000 PE CF
Avanti Research™ - A Croda Brand
Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (ammonium salt)
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About This Item
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Assay
>99% (TLC)
packaging
pkg of 1 × 1 mg (810120P-1mg)
pkg of 1 × 500 μg (810120P-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) lipid comprises hydrophilic polyethylene glycol (PEG) polymer in its head groups. DSPE-PEG(2000) micelles exist as spheroid in aqueous solution.
Application
18:0 PEG2000 PE CF may be used:
- in in vitro release assays from nanoemulsion (NE)
- for the labeling PEGylated LPD (liposome-polycation-DNA) for size exclusion chromatography studies
- as a fluorescent probe to monitor shape transformation in giant vesicles
Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) micelles aid in nanoparticles based drug delivery. It has potential to solubilize hydrophobic drugs and aid in the controlled release of drugs. 18:0 PEG2000 PE CF also called the DSPE−PEG2000, prevents the uptake of drugs by mononuclear phagocyte system and is a potential drug carrier for cancer therapy.
Packaging
5 mL Clear Glass Sealed Ampule (810120P-1mg)
5 mL Clear Glass Sealed Ampule (810120P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Molecular-matched materials for anticancer drug delivery and imaging
Wang D, et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(19), 3003-3013 (2015)
Morphology and physical properties of hydrophilic-polymer-modified lipids in supported lipid bilayers
Kakimoto Y, et al.
Langmuir, 34(24), 7201-7209 (2018)
Nanoparticles evading the reticuloendothelial system: role of the supported bilayer
Li SD and Huang L
Biochimica et Biophysica Acta - Biomembranes, 1788(10), 2259-2266 (2009)
Shape Transformations of Lipid Vesicles by Insertion of Bulky-Head Lipids
Tsuda S, et al.
PLoS ONE, 10(7), e0132963-e0132963 (2015)
Characterization of 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[Methoxy (polyethylene glycerol)-2000] and Its Complex with Doxorubicin Using Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics
Hu W, et al.
Bioconjugate Chemistry, 28(6), 1777-1790 (2017)
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