D5431
Diethylamine NONOate diethylammonium salt
≥98%
Synonym(s):
DEA NONOate, DEA/NO diethylammonium salt
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About This Item
Linear Formula:
(CH3CH2)2N–N(N=O)O- (CH3CH2)2NH2+
CAS Number:
Molecular Weight:
206.29
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.22
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description
t1/2 16 min phosphate buffer, 22 °C NO release
Assay
≥98%
form
solid
shipped in
dry ice
storage temp.
−70°C
SMILES string
CCNCC.CCN(CC)N(O)N=O
InChI
1S/C4H11N3O2.C4H11N/c1-3-6(4-2)7(9)5-8;1-3-5-4-2/h9H,3-4H2,1-2H3;5H,3-4H2,1-2H3
InChI key
LBJLVZKEUWCGIA-UHFFFAOYSA-N
Application
DEA/NO diethylammonium salt can be used as:
- A nitric oxide (NO) donor.
- A reagent for reductive nitrosylation of Wilkinson′s catalyst.
Used as:
- Reagent for reductive nitrosylation of Wilkinson′s catalyst
- Nitric oxide (NO) donor
Biochem/physiol Actions
NO donor
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Xi Ye et al.
The Journal of physiology, 596(16), 3553-3566 (2018-06-05)
Prolonged exposure to vascular endothelial growth factor A (VEGF-A) inhibits agonist-mediated endothelial cell Ca2+ release and subsequent activation of intermediate conductance Ca2+ -activated K+ (IKCa ) channels, which underpins vasodilatation as a result of endothelium-dependent hyperpolarization (EDH) in mouse resistance
Xin Zhang et al.
The Journal of biological chemistry, 277(50), 48472-48478 (2002-10-09)
4,5-Diaminofluorescein (DAF-2) is widely used for detection and imaging of NO based on its sensitivity, noncytotoxicity, and specificity. In the presence of oxygen, NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly fluorescent DAF-2 triazole (DAF-2T). However
Joseph C Galley et al.
Molecular pharmacology, 95(6), 629-637 (2019-04-17)
Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3',5'-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression attenuates vascular dilation and contributes to the pathogenesis of
Yi Shi et al.
PloS one, 9(9), e107787-e107787 (2014-09-24)
The aging gene p66Shc, is an important mediator of oxidative stress-induced vascular dysfunction and disease. In cultured human aortic endothelial cells (HAEC), p66Shc deletion increases endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) bioavailability via protein kinase B.
Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.
Rodolfo Urbano et al.
Cell host & microbe, 23(5), 594-606 (2018-05-01)
Staphylococcus aureus is a commensal bacterium that can asymptomatically colonize its host but also causes invasive infections. Quorum sensing regulates S. aureus virulence and the transition from a commensal to a pathogenic organism. However, little is known about how host innate
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