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Key Documents

SAB4500823

Sigma-Aldrich

Anti-PAR1 (Cleaved-Ser42), N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CXCR-7, CXCR7, G-protein coupled receptor 159, G-protein coupled receptor RDC1, chemokine orphan receptor 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 46 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

P25116

UniProt accession no.

P25116

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

proteolytically cleaved (Ser42)

Gene Information

human ... F2R(2149)

General description

Anti-PAR1 (Cleaved-Ser42) Antibody detects endogenous levels of fragment of activated PAR1 (Cleaved-Ser42) protein.
Protease-activated receptor-1 (PAR1), also known as coagulation factor II thrombin receptor (F2R), is encoded by the gene mapped to human chromosome 5q13.3. The encoded protein is a cell surface seven-transmembrane G protein coupled receptor.

Immunogen

The antiserum was produced against synthesized peptide derived from human PAR1.

Immunogen Range: 23-72

Application

Anti-PAR1 (Cleaved-Ser42), N-Terminal antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Protease-activated receptor-1 (PAR1) facilitates angiogenesis and influences the process of tumor growth and disease progression. In addition, it also plays a vital role in inflammation and thrombosis. Mutation in the gene is associated with an increased risk of metastasis and poorer prognosis of renal cell carcinoma. Elevated expression of the gene has been observed in various types of cancers, such as ovarian, breast, lung, prostate cancer and melanoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.
Swift S, et al.
The Journal of Biological Chemistry, 285(15), 11402-11410 (2010)
Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.
Plate M, et al.
Respirology, 20(8), 1285-1287 (2015)
The protease activated receptor 1 gene variation IVSn?14 A> T is associated with distant metastasis and cancer specific survival in renal cell carcinoma.
de Martino M, et al.
The Journal of Urology, 190(4), 1392-1397 (2013)
Li Kong et al.
Fundamental & clinical pharmacology, 36(3), 509-517 (2021-12-15)
Thrombin activity enhancement and its receptor protease-activated receptor 1 (PAR-1) activation play vital roles in neurologic deficits in the central nervous system. Our recent study showed that PAR-1 upregulation stimulated by chronic high glucose (HG) caused central neuron injury through
Barry S Shea et al.
JCI insight, 2(9) (2017-05-05)
Fibrotic lung disease, most notably idiopathic pulmonary fibrosis (IPF), is thought to result from aberrant wound-healing responses to repetitive lung injury. Increased vascular permeability is a cardinal response to tissue injury, but whether it is mechanistically linked to lung fibrosis
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