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D8399

Sigma-Aldrich

Danazol

≥98% (TLC), powder, androgen receptor agonist

Synonym(s):

17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole, 2,4,17α-Pregnadien-20-yno[2,3-d]­isoxa­zol-17-ol

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About This Item

Empirical Formula (Hill Notation):
C22H27NO2
CAS Number:
17230-88-5
Molecular Weight:
337.46
EC Number:
241-270-1
MDL number:
MFCD00056838
UNSPSC Code:
51111800
PubChem Substance ID:
24277708
NACRES:
NA.77

product name

Danazol, ≥98%

Assay

≥98%

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

originator

Sanofi Aventis

SMILES string

CC12Cc3cnoc3C=C1CCC4C2CCC5(C)C4CC[C@@]5(O)C#C

InChI

1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16?,17?,18?,20?,21?,22-/m0/s1

InChI key

POZRVZJJTULAOH-ZIKCMSSPSA-N

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Biochem/physiol Actions

Danazol is a weak androgen; anterior pituitary suppressant.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H312 + H332,H361

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Timothy J Craig
Allergy and asthma proceedings, 29(3), 225-231 (2008-04-05)
Hereditary angioedema (HAE) is an autosomal dominant disease characterized by painful, recurrent attacks of inflammation affecting the hands, feet, face, abdomen, urogenital tract, and the larynx. The inflammation can be disfiguring, debilitating, quite painful, and, in the case of laryngeal
H Farkas et al.
Allergy, 67(12), 1586-1593 (2012-10-03)
Hereditary angioedema is a potentially life-threatening disorder, because edema occurring in the mucosa of the upper airways can lead to suffocation. The management of HAE consists of avoiding the triggering factors, prophylaxis, and the acute treatment of edematous episodes. Medical
Pagalavan Letchumanan et al.
Seminars in arthritis and rheumatism, 40(4), 298-306 (2010-06-15)
To review and summarize published information on the use, effectiveness, and adverse effects of danazol in patients with systemic lupus erythematosus (SLE). A MEDLINE search from January 1950 to July 2009 was conducted using 2 search strategies retrieving 51 and
Johannes Parmentier et al.
International journal of pharmaceutics, 437(1-2), 253-263 (2012-09-04)
Liposomes are generally well tolerated drug delivery systems with a potential use for the oral route. However, little is known about the fate of liposomes during exposure to the conditions in the gastro-intestinal tract (GIT). To gain a better understanding
H Beaumont et al.
The Cochrane database of systematic reviews, (3)(3), CD001017-CD001017 (2007-07-20)
Heavy menstrual bleeding (HMB) is an important cause of ill health in pre menopausal women. Medical therapy, with the avoidance of possibly unnecessary surgery is an attractive treatment option, but there is considerable variation in practice and uncertainty about the
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