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Key Documents

07-344

Sigma-Aldrich

Anti-CPI-17 Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, pig, mouse, human, rabbit, bovine

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_033256

UniProt accession no.

Q96A00

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

bovine ... Ppp1R14A(615348)
human ... PPP1R14A(94274)
mouse ... Ppp1R14A(68458)
pig ... Ppp1R14A(397610)
rat ... Ppp1R14A(114004)

Specificity

CPI-17

Immunogen

Recombinant protein, full length pig CPI-17

Application

Anti-CPI-17 Antibody is an antibody against CPI-17 for use in WB.
NOT cross-reactive in yeast.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Quality

routinely evaluated by immunoblot on RIPA lysates from mouse brain nuclear fraction and pig carotid artery tissue extract

Target description

22kDa

Physical form

Format: Purified
PBS, 0.02% sodium azide before the addition of glycerol to 10%
Protein A chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation.
Ohki, S, et al.
Journal of Molecular Biology, 314, 839-849 (2001)
M Eto et al.
The Journal of biological chemistry, 276(31), 29072-29078 (2001-06-09)
Histamine stimulus triggers inhibition of myosin phosphatase-enhanced phosphorylation of myosin and contraction of vascular smooth muscle. In response to histamine stimulation of intact femoral artery, a smooth muscle-specific protein called CPI-17 (for protein kinase C-potentiated inhibitory protein for heterotrimeric myosin
Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor
Eto, M., et al
Neuron, 36, 1145-1158 (2002)
Young Jae Im et al.
American journal of physiology. Renal physiology, 313(2), F370-F377 (2017-04-28)
This study was performed to analyze the developmental changes in bladder response to cholinergic stimulation in detail, highlighting calcium sensitization (CS) and its related pathways. Rats were divided into three groups in accordance with reported time of developmental milestones (newborns
Ca2+-independent, inhibitory effects of cyclic adenosine 5'-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase C2alpha, Rho, and myosin phosphatase in vascular smooth muscle.
Azam, MA; Yoshioka, K; Ohkura, S; Takuwa, N; Sugimoto, N; Sato, K; Takuwa, Y
Journal of Pharmacology and Experimental Therapeutics null
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