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Sigma-Aldrich

NanoFabTx™-DC-Chol Lipid Mix

for synthesis of cationic (DC-cholesterol) liposomes

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

storage temp.

−20°C

General description

NanoFabTx™-DC-Chol Lipid Mix; for synthesis of cationic (DC-cholesterol) liposomes is a ready-to-use nanoformulation blend for the synthesis of liposomes for drug delivery. The NanoFabTx™-DC-Chol Lipid Mix includes optimized protocols with step-by-step instructions for synthesizing cationic DC-cholesterol liposomes for drug delivery applications. The modification of the liposomes with the cationic lipid, DC-cholesterol, have numerous advantages including high gene transfection efficiency. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.

Application

About NanoFabTx™

NanoFabTx™ lipid mixes and formulation kits enable users to encapsulate a wide variety of therapuetic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ reagent kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.

Features and Benefits

  • A ready-to-use nanoformulation blend for the synthesis of cationic DC-cholesterol liposomes
  • Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
  • Flexible synthesis tools to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • DC-Cholesterol allows for high transfection efficiency and targeted drug delivery
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol.
  • A microfluidics protocol using commercial platforms or syringe pumps.
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits are ready-to-use and include the microfluidic chip, fittings, and tubing required for microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications
Panahi Y, et al.
Artificial Cells, Nanomedicine, and Biotechnology (Print), 45, 788-799 (2017)
Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients.
Mayer LD, et al.
Biochimica et Biophysica Acta, 1025, 143-151 (1990)
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy
Papahadjopoulos D, et al.
Proceedings of the National Academy of Sciences of the USA, 88, 11460-11464 (1991)
Which polymers can make nanoparticulate drug carriers long-circulating?
Torchilin VP, et al.
Advanced Drug Delivery Reviews, 16, 141?155-141?155 (1995)
Daryl C Drummond et al.
Cancer research, 66(6), 3271-3277 (2006-03-17)
Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug delivery of this important class of anticancer drugs. We describe nanoliposomal CPT-11, a novel nanoparticle/liposome construct containing CPT-11 (irinotecan) with unprecedented
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