The solution stability is not determined. However, the literature suggests that the material is stable in solution at -80°C is for approximately 6 months; and -20°C for approximately 1 month.
PZ0233
PF-06424439
≥98% (HPLC)
Synonym(s):
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C22H26ClN7O · CH3SO3H
CAS Number:
Molecular Weight:
536.05
UNSPSC Code:
12352200
PubChem Substance ID:
Pricing and availability is not currently available.
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +7 to +11°, c = 1.0 in methanol
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
room temp
SMILES string
O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O
InChI
1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1
InChI key
ZSTFDNQQOJUJFL-XFULWGLBSA-N
Application
PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2) inhibitor:
- to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells[1]
- to study its effects on HeLa cells[2]
- to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells[3]
Biochem/physiol Actions
PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.[4]
PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
PF-06424439 is a potent, selective DGAT2 inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Kentaro Futatsugi et al.
Journal of medicinal chemistry, 58(18), 7173-7185 (2015-09-09)
The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1 with low lipophilic efficiency (LipE) was optimized through two key structural modifications: (1) identification of the pyrrolidine amide group for
Masaaki Uematsu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10357-10372 (2020-06-28)
Visualizing intracellular fatty acids (including free and esterified form) is very useful for understanding how and where such molecules are incorporated, stored, and metabolized within cells. However, techniques of imaging multiple intracellular fatty acids have been limited by their small
Leslie Magtanong et al.
Cell chemical biology, 26(3), 420-432 (2019-01-29)
The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We find that exogenous monounsaturated fatty acids (MUFAs) potently inhibit the non-apoptotic
Micah B Schott et al.
The Journal of cell biology, 218(10), 3320-3335 (2019-08-09)
Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a selective autophagic mechanism called lipophagy, but the relative contributions of these seemingly distinct pathways remain unclear. We find that inhibition of lipolysis, lipophagy, or both
Alexandre Santinho et al.
Current biology : CB, 30(13), 2481-2494 (2020-05-23)
Lipid droplet (LD) biogenesis begins in the endoplasmic reticulum (ER) bilayer, but how the ER topology impacts this process is unclear. An early step in LD formation is nucleation, wherein free neutral lipids, mainly triacylglycerols (TGs) and sterol esters (SEs)
-
What is the storage temperature once reconstituted in water?
1 answer-
Helpful?
-
-
I need the pharmacokinetics and pharmacodynamic study of PF-06424439 product, what is the half life of this DGAT 2 inhibitor please.
1 answer-
Unfortunately, pharmacokinetic, pharmacodynamic, and half-like information on this product are not available. The compound was developed by Pfizer, however, this product is intended for research use only. Some publications may be of interest.
See the link below for one such article.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01006#Helpful?
-
-
Hi, I want to inquire that if the PF-06424439 product could be dissolved into DMSO? Thanks.
1 answer-
The solubility of this compound is tested in water. The use of DMSO as a solvent has not been determined. However, external sources state that PF-06424439 can be solubilized in DMSO at approximately 50 mg/mL. This information has not been verified.
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
