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P8477

Sigma-Aldrich

Picotamide

Synonym(s):

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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About This Item

Empirical Formula (Hill Notation):
C21H20N4O3
CAS Number:
32828-81-2
Molecular Weight:
376.41
EC Number:
251-245-7
MDL number:
MFCD00866792
UNSPSC Code:
12352204
PubChem Substance ID:
24278656
NACRES:
NA.83

Assay

≥98%

Quality Level

100

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to light yellow

SMILES string

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

InChI key

KYWCWBXGRWWINE-UHFFFAOYSA-N

Gene Information

human ... TBXA2R(6915)

Biochem/physiol Actions

Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P L Malini et al.
Lancet (London, England), 350(9070), 15-18 (1997-07-05)
The increased prostaglandin synthesis that might follow stimulation of the arachidonic acid cascade by angiotensin-converting-enzyme inhibition (ACE-I) has been suggested to underlie the appearance of cough on ACE-I treatment. We investigated whether the prostanoid thromboxane was involved. Nine patients with
P Pancera et al.
Journal of internal medicine, 242(5), 373-376 (1998-01-04)
To assess the role of thromboxane A2 and of angiotensin II in patients with primary Raynaud's phenomenon. After an eight-day run-in period, the patients were enrolled in a single-blind, cross-over, study. Patients were examined at the Ambulatory for Microcirculatory Diseases
P Mura et al.
Drug development and industrial pharmacy, 24(8), 747-756 (1999-01-07)
The potential compatibilities of several commonly used pharmaceutical excipients with picotamide were evaluated using differential scanning calorimetry (DSC). The effects of aging and of mechanical treatment (blending, grinding, or kneading) of samples were also evaluated. Hot-stage microscopy (HSM) and scanning
M Berrettini et al.
European journal of clinical pharmacology, 39(5), 495-500 (1990-01-01)
Picotamide (G 137), a new non prostanoid inhibitor of in vitro arachidonic acid induced platelet aggregation, has been further characterized in in vitro and ex vivo studies. When whole blood was activated with collagen in the presence of picotamide 5
W Van Molle et al.
FEBS letters, 467(2-3), 201-205 (2000-02-17)
Tumor necrosis factor (TNF) induces hepatitis when injected in human beings or in rodents. The molecular mechanism by which TNF induces hepatic distress remains largely unknown, although induction of apoptosis of hepatocytes appears to be an essential step. In order
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