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P2443

Sigma-Aldrich

Pluronic® F-127

powder, BioReagent, suitable for cell culture

Synonym(s):

Non-ionic copolymer surfactant

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About This Item

Linear Formula:
(C3H6O·C2H4O)x
CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12161902
PubChem Substance ID:
24897874
NACRES:
NA.75

description

Non-ionic
contains 100ppm BHT

product line

BioReagent

form

powder

mol wt

~12600 g/mol

technique(s)

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

transition temp

cloud point >100 °C

HLB

18 - 23

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Related Categories

General description

Pluronicpluronic® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.

Application

Pluronic® F-127 has been used:

  • as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
  • as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
  • in the preparation of calcium indicator stock solution for measuring neural activities.
  • as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
  • This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.

Biochem/physiol Actions

Pluronic® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.

Legal Information

Pluronic is a registered trademark of BASF

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Federico Ceriani et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7194-E7201 (2016-11-04)
Spatially and temporally coordinated variations of the cytosolic free calcium concentration ([Ca2+]c) play a crucial role in a variety of tissues. In the developing sensory epithelium of the mammalian cochlea, elevation of extracellular adenosine trisphosphate concentration ([ATP]e) triggers [Ca2+]c oscillations
PLURONIC F127 and ITS applications
Salama AH
Pharmacology, 2, 1393- 1403 (2021)
NeuroCa: integrated framework for systematic analysis of spatiotemporal neuronal activity patterns from large-scale optical recording data
Jang MJ and Nam Y
Neurophotonics, 2(3) (2015)
Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding
Ghatnekar GS, et al.
Regenerative Medicine, 4(2), 205-223 (2009)
Philippe Marmottant et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17271-17275 (2009-10-07)
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If
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