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Key Documents

A0879

Sigma-Aldrich

N-(4-Aminobenzoyl)-L-glutamic acid

≥98% (TLC)

Synonym(s):

N-(p-Aminobenzoyl)glutamic acid

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O5
CAS Number:
Molecular Weight:
266.25
Beilstein:
2816320
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

Product Name

N-(4-Aminobenzoyl)-L-glutamic acid, ≥98% (TLC)

Assay

≥98% (TLC)

form

powder

color

off-white to beige

mp

175 °C (dec.)

application(s)

detection
peptide synthesis

storage temp.

−20°C

SMILES string

Nc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1

InChI key

GADGMZDHLQLZRI-VIFPVBQESA-N

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Application

N-(4-Aminobenzoyl)-L-glutamic acid (ABG) is used as a strong UV absorbing tag for the derivitization of oligosaccharides to enhance their detection in analytical methods such as capillary zone electrophoresis (CZE).

Biochem/physiol Actions

N-p-Aminobenzoyl)-L-glutamic acid is a folate catabolite that can be metabolized by bacterial p-aminobenzoate auxotrophs possessing the enzyme p-aminobenzoyl-glutamate hydrolase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J Plocek et al.
Journal of chromatography. A, 757(1-2), 215-223 (1997-01-03)
A charged and strongly UV-absorbing tag, N-(4-aminobenzoyl)-L-glutamic acid) (ABG), was coupled to oligosaccharides by reductive amination under mild conditions. The effectiveness of ABG as a derivatization agent is shown through the separation of isomaltooligosaccharides from a dextran hydrolysate. The minimum
SreeDivya Saladi et al.
Molecular cell, 77(1), 189-202 (2019-11-02)
The proteolytic turnover of mitochondrial proteins is poorly understood. Here, we used a combination of dynamic isotope labeling and mass spectrometry to gain a global overview of mitochondrial protein turnover in yeast cells. Intriguingly, we found an exceptionally high turnover
Rita Hannisdal et al.
Clinical chemistry, 54(4), 665-672 (2008-02-19)
The development of accurate and precise folate assays has been difficult, mainly because of folate instability. Large interassay and interlaboratory differences have been reported. We therefore developed a serum folate assay that measures folate and putative degradation products as p-aminobenzoylglutamate
J R Higgins et al.
BJOG : an international journal of obstetrics and gynaecology, 107(9), 1149-1154 (2000-09-26)
To estimate the rate of folate catabolism in pregnant and nonpregnant women and to derive the recommended dietary allowance for folate. Prospective, observational study. Rotunda Hospital, Dublin. WOMEN: Twenty-four healthy gravid women were studied once during each trimester and postpartum.
J F Gregory et al.
The Journal of nutrition, 131(7), 1928-1937 (2001-07-04)
To investigate the effects of pregnancy on folate metabolism, we conducted an 84-d study in second-trimester (gestational wk 14-25) pregnant women (n = 6) and nonpregnant controls (n = 6) with stable-isotopic tracer methods. All subjects were fed a diet

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