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30030

Sigma-Aldrich

Cymarin

≥96% (HPLC)

Synonym(s):

K-Strophanthidin-D-cymaroside, K-Strophanthin-α

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About This Item

Empirical Formula (Hill Notation):
C30H44O9
CAS Number:
508-77-0
Molecular Weight:
548.66
Beilstein:
101370
EC Number:
208-087-9
MDL number:
MFCD00003669
UNSPSC Code:
12352211
PubChem Substance ID:
57648403
NACRES:
NA.77
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Quality Level

100

Assay

≥96% (HPLC)

SMILES string

CO[C@H]1C[C@@H](O[C@H](C)[C@H]1O)O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6

InChI

1S/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22-,23+,25+,26-,27-,28+,29+,30+/m1/s1

InChI key

XQCGNURMLWFQJR-ZNDDOCHDSA-N

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Application

Cymarin was used to study the effect of cardiac glycosides on vascular smooth muscles[1] and ion transport.[2]

Biochem/physiol Actions

Cymarin is a cardiac glycoside and is classified as cardiotonic steroid. It inhibits ion transport by decreasing the activity of (Na-K)-ATPase.[2] [3]

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301 + H331,H373

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC9196
BCCB2296
BCBX6134
BCBW0159
BCBS9934

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[Anti-arrhythmic effect of indomethacin in experimental studies].
V M Sambelian et al.
Kardiologiia, 28(2), 88-90 (1988-02-01)
C Giunta et al.
General pharmacology, 16(3), 183-188 (1985-01-01)
Ouabain and K-strophanthoside promote an enhancement of Na+/K+-ATPase activity in a range of cardioglycoside concentrations from 100 nM to 100 pM, with a maximum (+30%) between 10 and 4 nM. Binding experiments with [3H]ouabain show upward-curved Scatchard plots and evidence
Increased in vivo synthesis of retinal Na pump isoforms after pre-treatment with citrate buffer.
S C Specht et al.
Progress in clinical and biological research, 268B, 143-147 (1988-01-01)
[Effect of strophanthin, digoxin and isoproterenol on heart contractility in hypoxia and hypercapnic acidosis].
G T Yang et al.
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 6(4), 199-205 (1986-01-01)
H Ozaki et al.
The Journal of pharmacology and experimental therapeutics, 231(1), 153-158 (1984-10-01)
The effects of ouabain and other cardiotonic steroids were examined to investigate whether changes in Na,K-adenosine triphosphatase (ATPase) activity modified the actions of palytoxin (PTX) in rabbit aortic vascular smooth muscle. The effects of these agents on rabbit aorta were
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