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Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

Synonym(s):

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
31961-02-1
MDL number:
MFCD00284260
UNSPSC Code:
51171641
NACRES:
NA.26

form

powder

Quality Level

100

mol wt

Mr ~2100

mp

50-53 °C

Ω-end

carboxylic acid

α-end

methoxy

storage temp.

−20°C

Application

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

Biochem/physiol Actions

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
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Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
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Journal of peptide science : an official publication of the European Peptide Society, 8(9), 529-542 (2002-10-10)
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