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SMB01374

Sigma-Aldrich

16α-Hydroxydehydroepiandrosterone

≥95% (HPLC)

Synonym(s):

(3β,16α)-3,16-Dihydroxyandrost-5-en-17-one, 16α-Hydroxy-DHEA, 16α-OH-DHEA, 16OH-DHEA, 16alpha-Hydroxy-DHEA, 16alpha-Hydroxydehydroepiandrosterone, 16alpha-OH-DHEA, 3,16-Dihydroxyandrost-5-en-17-one, 5-Androsten-3β,16α-diol-17-one, Androst-5-ene-3β-16α-diol-17-one

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About This Item

Empirical Formula (Hill Notation):
C19H28O3
CAS Number:
1232-73-1
Molecular Weight:
304.42
MDL number:
MFCD00056396
UNSPSC Code:
12352211
UNSPSC Code:
51182012
NACRES:
NA.21

biological source

synthetic

Quality Level

200

Assay

≥95% (HPLC)

form

solid

storage temp.

2-8°C

InChI

1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1

InChI key

QQIVKFZWLZJXJT-DNKQKWOHSA-N

Application

16α-Hydroxydehydroepiandrosterone (16OH-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone (DHEA). It is formed upon 16-hydroxylation by the cytochrome P450 (CYP) enzyme CYP3A4 and fetal/neonatal form CYP3A7. 16OH-DHEA is the precursor of fetal 16alpha-hydroxylated estrogens, the main phenolic steroids in pregnancy. Their serum levels are used as biochemical markers of the well being of the fetus. In adults, increased levels of 16-hydroxylated estrogens are thought to correlate with the risk of cancer and some systemic autoimmune diseases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000204123
0000204122

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Qing-Feng Xie et al.
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Zhen-Biao Zhang et al.
Frontiers in pharmacology, 9, 1181-1181 (2018-11-06)
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of

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