Skip to Content
Merck
All Photos(1)

Key Documents

544639

Sigma-Aldrich

Methanesulfonylacetone

97%

Synonym(s):

1-(Methylsulfonyl)-2-propanone, NSC 35395

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
CH3C(O)CH2SO2CH3
CAS Number:
Molecular Weight:
136.17
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

97%

form

powder or crystals

mp

48-52 °C (lit.)

SMILES string

CC(=O)CS(C)(=O)=O

InChI

1S/C4H8O3S/c1-4(5)3-8(2,6)7/h3H2,1-2H3

InChI key

NWEYGXQKFVGUFR-UHFFFAOYSA-N

General description

Methanesulfonylacetone is a sulfonyl group-containing active methylene compound. It can react with Baylis–Hillman acetates in dimethylformamide/potassium carbonate system to form ortho-hydroxyacetophenone derivatives.

Application

Methanesulfonylacetone may be used in the preparation of 6-bromo-3-methanesulfonyl-2-methyl-quinolin-4-ol.
Reactant for:
  • Stereoselective preparation of chiral cyclic ketones
  • Preparation of poly-substituted pyridines
  • Multicomponent cyclocondensation with aldehydes and aminoazoles
  • Gold-catalyzed Friedlander cyclocondensation reaction
  • Radical homoallylation reactions

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Synthesis of ortho-hydroxyacetophenone derivatives from Baylis?Hillman acetates.
Kim JN, et al.
Tetrahedron Letters, 43(37), 6597-6600 (2007)
New vistas in quinoline synthesis.
Atechian S, et al.
Tetrahedron, 63(13), 2811-2823 (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service