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Sigma-Aldrich

4-Bromo-1-fluoro-2-nitrobenzene

96%

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About This Item

Linear Formula:
BrC6H3(F)NO2
CAS Number:
364-73-8
Molecular Weight:
220.00
MDL number:
MFCD00129165
UNSPSC Code:
12352100
PubChem Substance ID:
24878380
NACRES:
NA.22

Assay

96%

refractive index

n20/D 1.575 (lit.)

bp

240-241 °C (lit.)

mp

18-19 °C (lit.)

density

1.786 g/mL at 25 °C (lit.)

SMILES string

[O-][N+](=O)c1cc(Br)ccc1F

InChI

1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H

InChI key

UQEANKGXXSENNF-UHFFFAOYSA-N

General description

4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product.

Application

4-Bromo-1-fluoro-2-nitrobenzene may be used in the synthesis of:
  • 6-bromo-1H-benzo[d][1,2,3]triazol-1-ol
  • 2-(4-bromo-2-nitrophenylamino)-5-methylthiophene-3-carbonitrile
  • dibenzoxazepine analog, as potent sodium channel blocker
  • 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylic acid tert-butylester
Used in the synthesis of anti-inflammatory agents.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium bis(trimethylsilyl)amide as a base. Moderate to excellent yields of 2-ethynylnitrobenzene products can be obtained under mild conditions.
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Bioorganic & medicinal chemistry letters, 25(1), 43-47 (2014-12-04)
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
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